The transcriptionally permissive chromatin state of ES cells is acutely tuned to translational output

1 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA 2 Department of Pharmaceutical Chemistry, Mass Spectrometry Facility, School of Pharmacy, UCSF, San Francisco, CA 94158, USA 3 UCSF Diabetes Center, WM Keck Center for Noncoding RNAs, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA 4 Department of Neurological Surgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA 5 These authors contributed equally. * Correspondence: Miguel Ramalho-Santos: [email protected]